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In addition, several animal-based and human studies suggested analgesic properties of nicotine via affecting central and peripheral nicotine acetylcholine receptors and indicate that chronic exposure to smoking may alter pain perception among smokers compared to non-smokers

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Both prewash ( P -value=0.0009) and postwash hand ( P -value=0.01) samples were positively correlated with leaf-wipe concentrations

[PubMed: 10402220] OConnor RJ, Hurley PJ

Condition: crinkled around the edges, missing pieces on upper left side